HNSCC 137P spheroid · NK-92MI co-culture · OncoMiMIC chip
The OncoMiMIC Platform

Watch the tumor lose.

OncoMiMIC recreates the tumor microenvironment on a chip — capturing immune cell recruitment, infiltration, and cytolytic kill as it happens.

How the chip works → Request a pilot study
T+00:00
Elapsed · 20-min intervals
Tumor signal
−41%
NK effectors
+177%
Tumor spheroid NK-92MI effector cells
TRL 5 chip 5+ outputs per experiment 5–20× faster analysis 30–144 data points per chip Scalable 4-plex → 36-plex
The technology

A compartmentalized chip with four functional zones.

Effector cells are introduced outside an artificial barrier of microstructures. They are recruited across it, infiltrate the tumor compartment, and kill — every step measured automatically.

Zone 0 — Tumor seeding zone
Holds 3D patient-derived spheroids in a controlled microenvironment.
Zone 1 — Tumor–immune interaction zone
Where effector cells engage the tumor. Precise E:T ratio control and monitoring.
Zone 2 — Barrier zone
A micropillar array that immune cells must actively migrate through — making recruitment and infiltration directly quantifiable.
Zone 3 — Immune fluidic zone
Effector cell reservoir. Cells are recovered here after the run for downstream transcriptomics.
Compatible with standard microscope slides and well-plate footprints — OncoMiMIC drops into the equipment your lab already owns.
Scientific foundation

Why 3D changes the answer.

2D well plateOncoMiMIC 3D chip
MorphologyFlat, elongatedNative 3D shape
Gene expressionFar from patient tissueMatches in-vivo signatures
Drug sensitivityUnderestimates doseAccurate resistance modeling
Cell communicationPoor junctionsFunctional, quantifiable contact
Throughput1 well = 1 data point1 chip > 30–144 points
3D cultures yield 2–6× higher IC50 values than 2D — standard assays systematically underestimate the dose needed for real clinical effect.
Data advantage

5+ rich outputs from a single experiment.

01Immune cell recruitment
02Immune cell infiltration
03Immune-mediated cytotoxicity
04Spatial dynamics — AI-tracked, longitudinal
05Gene expression — recovered cells, same run

Each run links phenotype to genotype — enabling earlier “kill early, kill cheap” decisions at the stages where they save the most.

Validation

Built on published science, validated with partners.

Global CRO partnership

A proof-of-concept project running now, with roughly $50K SGD of in-kind services. All IP developed belongs to the company.

In progress

Peer-reviewed foundation

Multi-compartment microfluidic work dissecting immune–epithelial interactions, published in Bioengineering & Translational Medicine.

Published

Granted US patent

Core microfluidics IP licensed from A*STAR, with our CSO named as inventor.

Granted

Run your assay on OncoMiMIC.

We are onboarding pharma and CRO partners for pilot validation studies. Tell us the indication and assay type, and we will come prepared.

Request a pilot study →